Kcn serial macro5/24/2023 High concentrations of antiserum inhibited metabolic activity. Metabolic studies revealed that low concentrations of antiserum stimulated consumption of oxygen and hexose-monophosphate-shunt (HMS) activity without significantly affecting production of lactate these metabolic changes were similar to those during phagocytosis. The stages of attachment and ingestion were prolonged by exposure to 1%-2% antiserum, and it became possible to distinguish between them. Morphologic observations revealed agglutination and loss of ability to adhere to glass at low concentrations (0.2%-2%) and vacuolization with cell death at high concentrations of antisera (10%). All four antisera produced identical changes in peritoneal macrophages. Antisera to peritoneal macrophages (AMS), pulmonary macrophages, lymphocytes (ALS), and renal tissue were produced by injection of suspensions of guinea-pig cells into rabbits.
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